EFFECTS OF BLOOD TRANSMISSION REACTION

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 Blood cells are attacked by the recipient's plasma agglutinins during a transfusion reaction when mismatched blood is transfused.Small blood vessels across the body clot as a result of the original occurrence, which is the agglutination of the foreign red blood cells.In the hours that follow, the clumped red blood cells start to break apart or are eaten by phagocytes, releasing their hemoglobin into the bloodstream. Additionally, transfusion responses can lead to general toxicity, nausea, vomiting, low blood pressure, chills, and low blood sugar: The goal of treating transfusion responses is to avoid renal injury by giving fluids and diuretics to improve urine flow, diluting and washing away the hemoglobin. Two clearly defined issues result from these circumstances. (1) The transfused blood cells' ability to transport oxygen is compromised, and (2) the clumping of red blood cells in tiny veins reduces blood flow to organs beyond those locations. Renal shutdown and cell death are brought on by circulating hemoglobin, which readily enters the kidney tubules. The person may pass away if there is a total shutdown (acute renal failure).

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